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KMID : 0381219820140020053
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Journal of RIMSK
1982 Volume.14 No. 2 p.53 ~ p.60
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A Clinical Study on Serum Lipid and Hemoglobin Alc in Adult Onset Diabetics
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Abstract
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Diabetes Mellitus is the most common of the serious metabolic diseases of human and its frequency in the general population is nowdays increasing.
The diabetic patient is, unfortunately, susceptible to a series of complications that lead to considerable morbidity and premature mortality.
The syndrome can be completely asymptomatic, or it can appear as an isolated disorder of any organ or system, therefore, early detection of metabolic abnormalities of diabetes and well balanced control of hyperglycemia is important for preventing, or, at least, delaying its serious life treatening complication although there are still many controversies about a causal relationship between hyperglycemia and complications.
In this study of diabetic patients, we have examined various metabolic expressions of diabetes, namely, blood glucose concentration, hemoglobin Alc, HDL-cholesterol and their relation to age, sex, blood glucose level, duration of disease, vascular complications and treatment.
The. results are as follows.
1. The average serum Hb Alc was 6.9% (S. D.0.9%) in normal control group and 10.9% (S. D. 1.3%) in adult onset diabetic patients. (P<0.05)
2. The serum Hb Alc level was increased according to the elevation of FBS and PP 2hr glucose level.
3. The average serum HDL-cholestrol concentration was 46.0mg/dl (S. D. 5.2mg/dl) in normal control group and 41.2mg/dl (S. D. 4.8mg/dl). in adult onest diabetic patients. Its level was- significanaly reduced in diabetics. (P < 0.05)
4. The changes of serum Hb Alc and HDL-cholesterol level according to the duration of disease was not constant.
5. The higher the fasting blood sugar concentration, the lower the serum HDL-cholesterol level. There was a
tendency of inverse correlation between Hb Alc level and HDL-cholesterol concentration.
6. There was no difference in serum Hb Alc and HDL-cholesterol level among underweight, ideal weight, and overweight groups.
7. The serum HDL-cholesterol level was lower in patients with vascular complication than in patients without
vascular complication. (P<0.05) There was no significant difference in serum Hb Alc between two grcup~ 8. After treatment with insulin or oral hypoglycemic agent for 2 months, there was significant increase in´ HDL-Cholesterol level and significant reduction in Hb AIc level. (P<0.05)
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